Bioheterocycles 2019

XVIII International Conference on Heterocycles in Bioorganic Chemistry

 Ghent, Belgium    June 17-20, 2019

Programme

Click on the day below to see the detailed programme.

08:00

Registration

09:10

Opening

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

Session 1

Session Chair

Prof. Christian STEVENS
GHENT UNIVERSITY, Ghent, Belgium

09:30

Heterocycles as Key Features of New Starting Points for Drug Discovery (PL01)

Dr Peter MEIER
NOVARTIS PHARMA AG, Basel, Switzerland

10:15

Development of Enzyme Inhibitors and Multi-target-directed Ligands for Treating Neurodegenerative Diseases (IL01)

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

10:45

Coffee break

Session 2

Session Chair

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:15

Silil-Prins Cyclization: Towards the Synthesis of Medium Sized Heterocycles (OC01)

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:30

Chiral Piperidines from Pyridines: the Meta-Substitution Challenge in Asymmetric Hydrogenation (OC02)

Dr Paul ALSTERS
INNOSYN B.V., Geleen, The Netherlands

11:45

Expanding the Chemical Space of Chiral Trifunctional Building Blocks by Stereoselective Synthesis from Natural Terpenes (IL02)

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

12:15

Lunch

Session 3

Session Chair

Prof. Fawaz ALDABBAGH
KINGSTON UNIVERSITY, London, United Kingdom

13:30

A Journey in Heteroaromatic Scaffolds as Protein Kinase Inhibitors (PL02)

Prof. Pascale MOREAU
UNIVERSITY OF CLERMONT AUVERGNE, Aubičre, France

14:15

Bacterial Quinolones and Derivatives: New Drugs for Bad Bugs (IL03)

Dr Thomas BOTTCHER
UNIVERSITY OF KONSTANZ, Konstanz, Germany

14:45

Hydrogen Peroxide and Hydrohalic Acid-Mediated Synthesis of Ring-Fused Benzimidazolequinone Anti-Cancer Agents (OC03)

Mr Darren CONBOY
KINGSTON UNIVERSITY LONDON, Kingston upon Thames, United Kingdom

15:00

Coffee break

Session 4

Session Chair

Dr Bart ROMAN
GHENT UNIVERSITY, Ghent, Belgium

15:30

Thionations Using a P4S10-Pyridine Complex (OC04)

Ms Ngarita KINGI
VIRONOVA MEDICAL AB, Stockholm, Sweden

15:45

First Solid-Phase Strategy for the Total Synthesis of Fengycin Derivatives, a Class of Cyclic Lipodepsipeptides (OC05)

Dr Lidia FELIU
LIPPSO, UNIVERSITY OF GIRONA, Girona, Spain

16:00

Design and Synthesis of New Nitrogen-Containing Heterocycles for the Treatment of Mechanical Allodynia (OC06)

Ms Alexia VISSEQ
INSTITUT DE CHIMIE DE CLERMONT FERRAND, AUBIERE, France

16:15

Poster Session

18:00

Welcome Reception (Ghent City Hall)

Session 5

Session Chair

Prof. Bert MAES
UNIVERSITY OF ANTWERP, Antwerp, Belgium

09:00

Heterocycles To Control Immune Cell Function (PL03)

Prof. David FAIRLIE
UNIVERSITY OF QUEENSLAND, Brisbane, Australia

09:45

Vitamin B12 – an Intriguing Bioheterocycle (IL04)

Prof. Dorota GRYKO
INSTITUTE OF ORGANIC CHEMISTRY PAS, Warsaw, Poland

10:15

Hydroxylated Heterocycles as a Bioisosteric Tool to Modulate the Carboxylic Function (OC08)

Dr Agnese Chiara PIPPIONE
UNIVERSITY OF TURIN, Torino, Italy

10:30

Tweaking the Blebbistatin Scaffold Towards Better Pharmacological Tools (OC09)

Dr Bart ROMAN
GHENT UNIVERSITY, Ghent, Belgium

10:45

Coffee break

Session 6

Session Chair

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:15

The Magic of Wood and Light – New Concepts for Synthetic Chemistry (OC10)

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:30

Synthesis of Enantioenriched 3-Isobenzofuranones Using Chiral Organomagnesiates (OC11)

Dr Sabrina TOUCHET
UNIVERSITÉ DE LORRAINE, Vandoeuvre-les-Nancy, France

11:45

Functionalization of Aromatic Heterocycles Using Bases Derived from LiTMP (IL05)

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

12:15

Lunch

Session 7

Session Chair

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

13:30

Synthesis of Heterocyles Using Visible Light Photocatalysis (PL04)

Prof. Burkhard KÖNIG
UNIVERSITY OF REGENSBURG, Regensburg, Germany

14:15

Leveraging Carbonylation and N-acyl imine Chemistry in Heterocycle Synthesis (IL06)

Dr Luke ODELL
UNIVERSITY OF UPPSALA, Uppsala, Sweden

14:45

Structurally Simple Cytosine Peptidomimetics as Potent Cardioprotectors in Myocardial Ischemia (MI) Mouse Model: Design, Synthesis And Biological Evaluation (OC12)

Dr Edward KORSHIN
BAR-ILAN UNIVERSITY, Ramat Gan, Israel

15:00

Biradical Formation by Deprotonation in Conjugated 2-Amino/Imino Thiazole Derivatives (OC13)

Prof. Francisco LOPEZ-CALAHORRA
UNIVERSITAT DE BARCELONA, Barcelona, Spain

16:00

Excursion

Session 8

Session Chair

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

09:00

The Beautiful Simplicity of Rearrangements (PL05)

Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria

09:45

A journey with Saponins (IL07)

Dr Martina LAHMANN
BANGOR UNIVERSITY, Wales, United Kingdom

10:15

Small but Selective: Developing Chemical Probes for PKN/PRK2 (OC14)

Ms Fiona SCOTT
SUSSEX DRUG DISCOVERY CENTRE, Falmer, United Kingdom

10:30

Application of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles (OC15)

Dr Olivier LORTHIOIR
ASTRAZENECA, Cambridge, United Kingdom

10:45

Coffee break

Session 9

Session Chair

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

11:15

The Phenanthridine PJ-34 Exclusively Eradicates Human cancer Cells (OC16)

Prof. Malka COHEN-ARMON
TEL-AVIV UNIVERSITY, Tel-Aviv, Israel

11:30

Synthesis and in vitro -Glucosidase Inhibitory Activity of Polyhydroxylated 2-Styrylchromones (OC17)

Dr Clementina SANTOS
INSTITUTO POLITÉCNICO DE BRAGANÇA, Braganca, Portugal

11:45

Heterocycles and Neglected Diseases: Still a Role for Total Synthesis (IL08)

Prof. Adrian DOBBS
UNIVERSITY OF GREENWICH, Kent, United Kingdom

12:15

Lunch

Session 10

Session Chair

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

13:30

Multiple Conjugation Reactions on Peptides and Oligonucleotides (PL06)

Prof. Anna GRANDAS
UNIVERSITY OF BARCELONA, Barcelona, Spain

14:15

Heterocycles as a Route to New Chemical Space for Drug Discovery (IL09)

Prof. James BULL
IMPERIAL COLLEGE, London, United Kingdom

14:45

'Stretched' Analogs of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery (OC18)

Dr Ivan KONDRATOV
ENAMINE, Kiev, Ukraine

15:00

Coffee break

Session 11

Session Chair

Dr Thomas HEUGEBAERT
UGENT, Gent, Belgium

15:30

Biologically Active Oxygen and Nitrogen Heterocyclic Compounds from Cycloaddition and Conjugate Addition Reactions On Chromones (OC19)

Prof. Artur M.S. SILVA
UNIVERSITY OF AVEIRO, Aveiro, Portugal

15:45

Combining Isocyanides with Carbon Dioxide for Heterocycle Synthesis (OC20)

Mr Jeroen BOMON
UNIVERSITEIT ANTWERPEN, Antwerpen, Belgium

16:00

Kolbe Anodic Decarboxylation as a Green Way to Access Pyrrolidinones (OC21)

Ms Mathilde QUERTENMONT
UNIVERSITÉ CATHOLIQUE DE LOUVAIN, La Hulpe, Belgium

16:15

Playing with Properties of Biologically Active Compounds: High-Throughput Conjugation of Drug-Like Molecules for Chemical Biology (OC22)

Ms Sona KRAJCOVICOVA
PALACKY UNIVERSITY, Olomouc, Czech Republic

16:30

Poster Session

19:00

Symposium Banquet

Session 12

Session Chair

Prof. Sven MANGELINCKX
GHENT UNIVERSITY, Ghent, Belgium

10:00

Heterocyclic Chemistry in Drug Development (PL07)

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

10:45

Biologically Active Azaheterocycles Containing a Ferrocene Moiety (IL10)

Prof. Niko S. RADULOVIC
UNIVERSITY OF NIS, Nis, Serbia

11:15

Regioselective C-H Arylation of Nitro Heterocycles and Further Transformation of Manipulable Nitro Group (OC23)

Dr Viktor IAROSHENKO
POLISH ACADEMY OF SCIENCES, Lodz, Poland

11:30

Towards DNA-Encoded Heterocycle Libraries - DNA-Compatible Povarov and Groebke Reactions by Micellar Broensted Acid Catalysis (OC24)

Dr Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany

11:45

Closing and Award ceremony

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

12:00

Lunch