Bioheterocycles 2019

XVIII International Conference on Heterocycles in Bioorganic Chemistry

 Ghent, Belgium    June 17-20, 2019

Programme

Click on the day below to see the detailed programme.

08:00

Registration

09:10

Opening

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

Session 1

Session Chair

Prof. Christian STEVENS
GHENT UNIVERSITY, Ghent, Belgium

09:30

PL01 - Heterocycles as Key Features of New Starting Points for Drug Discovery

Dr Peter MEIER
NOVARTIS PHARMA AG, Basel, Switzerland

10:15

IL01 - Development of Enzyme Inhibitors and Multi-target-directed Ligands for Treating Neurodegenerative and Autoimmune Diseases

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

10:45

Coffee break

Session 2

Session Chair

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:15

OC01 - Silil-Prins Cyclization: Towards the Synthesis of Medium Sized Heterocycles

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:30

OC02 - Chiral Piperidines from Pyridines: the Meta-Substitution Challenge in Asymmetric Hydrogenation

Dr Paul ALSTERS
INNOSYN B.V., Geleen, The Netherlands

11:45

IL02 - Expanding the Chemical Space of Chiral Trifunctional Building Blocks by Stereoselective Synthesis from Natural Terpenes

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

12:15

Lunch

Session 3

Session Chair

Prof. Fawaz ALDABBAGH
KINGSTON UNIVERSITY, London, United Kingdom

13:30

PL02 - A Journey in Heteroaromatic Scaffolds as Protein Kinase Inhibitors.

Prof. Pascale MOREAU
UNIVERSITY OF CLERMONT AUVERGNE, Aubičre, France

14:15

IL03 - Bacterial Quinolones and Derivatives: New Drugs for Bad Bugs

Dr Thomas BOTTCHER
UNIVERSITY OF KONSTANZ, Konstanz, Germany

14:45

OC03 - Hydrogen Peroxide and Hydrohalic Acid-Mediated Synthesis of Ring-Fused Benzimidazolequinone Anti-Cancer Agents

Mr Darren CONBOY
KINGSTON UNIVERSITY LONDON, Kingston upon Thames, United Kingdom

15:00

Coffee break

Session 4

Session Chair

Dr Bart ROMAN
GHENT UNIVERSITY, Ghent, Belgium

15:30

OC04 - Thionations Using a P4S10 -Pyridine Complex

Ms Ngarita KINGI
VIRONOVA MEDICAL AB, Stockholm, Sweden

15:45

OC05 - First Solid-Phase Strategy for the Total Synthesis of Fengycin Derivatives, a Class of Cyclic Lipodepsipeptides

Dr Lidia FELIU
LIPPSO, UNIVERSITY OF GIRONA, Girona, Spain

16:00

OC06 - Design and Synthesis of New Nitrogen-Containing Heterocycles for the Treatment of Mechanical Allodynia

Ms Alexia VISSEQ
INSTITUT DE CHIMIE DE CLERMONT FERRAND, AUBIERE, France

16:15

OC07 - ZN(OTF)2-Catalyzed Synthesis of 2-Alkynylazetidines and their Ring Expansion to Functionalized 1,4,5,6-Tetrahydropyridines

Dr Aaliya SHEHZADI
INTERNATIONAL ISLAMIC UNIVERSITY, Islamabad, Pakistan

16:30

Poster Session

18:00

Welcome Reception (Ghent City Hall)

Session 5

Session Chair

Prof. Bert MAES
UNIVERSITY OF ANTWERP, Antwerp, Belgium

09:00

PL03 - Heterocycles To Control Immune Cell Function

Prof. David FAIRLIE
UNIVERSITY OF QUEENSLAND, Brisbane, Australia

09:45

IL04 - Vitamin B12 – an Intriguing Bioheterocycle

Prof. Dorota GRYKO
INSTITUTE OF ORGANIC CHEMISTRY PAS, Warsaw, Poland

10:15

OC08 - Hydroxylated Heterocycles as a Bioisosteric Tool to Modulate the Carboxylic Function

Dr Agnese Chiara PIPPIONE
UNIVERSITY OF TURIN, Torino, Italy

10:30

OC09 - Nanomachine Biocatalysts: Enzymatic Fusions with Tethered Cofactors for Sustainable Industrial Chemistry

Dr Andrea NORTH
CSIRO, Parkville, Australia

10:45

Coffee break

Session 6

Session Chair

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:15

OC10 - The Magic of Wood and Light – New Concepts for Synthetic Chemistry

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:30

OC11 - Synthesis of Enantioenriched 3-Isobenzofuranones Using Chiral Organomagnesiates

Dr Sabrina TOUCHET
UNIVERSITÉ DE LORRAINE, Vandoeuvre-les-Nancy, France

11:45

IL05 - Functionalization of Aromatic Heterocycles Using Bases Derived from LiTMP

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

12:15

Lunch

Session 7

Session Chair

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

13:30

PL04 - Synthesis of Heterocyles Using Visible Light Photocatalysis

Prof. Burkhard KÖNIG
UNIVERSITY OF REGENSBURG, Regensburg, Germany

14:15

IL06 - Leveraging Carbonylation and N-acyl imine Chemistry in Heterocycle Synthesis.

Dr Luke ODELL
UNIVERSITY OF UPPSALA, Uppsala, Sweden

14:45

OC12 - Structurally Simple Cytosine Peptidomimetics as Potent Cardioprotectors in Myocardial Ischemia (MI) Mouse Model: Design, Synthesis And Biological Evaluation

Dr Edward KORSHIN
BAR-ILAN UNIVERSITY, Ramat Gan, Israel

15:00

OC13 - Biradical Formation by Deprotonation in Conjugated 2-Amino/Imino Thiazole Derivatives

Prof. Francisco LOPEZ-CALAHORRA
UNIVERSITAT DE BARCELONA, Barcelona, Spain

16:00

Excursion

Session 8

Session Chair

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

09:00

PL05 - The Beautiful Simplicity of Rearrangements

Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria

09:45

IL07 - A journey with Saponins

Dr Martina LAHMANN
BANGOR UNIVERSITY, Wales, United Kingdom

10:15

OC14 - Small but Selective: Developing Chemical Probes for PKN/PRK2

Ms Fiona SCOTT
SUSSEX DRUG DISCOVERY CENTRE, Falmer, United Kingdom

10:30

OC15 - Application of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles

Dr Olivier LORTHIOIR
ASTRAZENECA, Cambridge, United Kingdom

10:45

Coffee break

Session 9

Session Chair

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

11:15

OC16 - The Phenanthridine PJ-34 Exclusively Eradicates Human cancer Cells

Prof. Malka COHEN-ARMON
TEL-AVIV UNIVERSITY, Tel-Aviv, Israel

11:30

OC17 - Synthesis and in vitro -Glucosidase Inhibitory Activity of Polyhydroxylated 2-Styrylchromones

Dr Clementina SANTOS
INSTITUTO POLITÉCNICO DE BRAGANÇA, Braganca, Portugal

11:45

IL08 - Heterocycles and Neglected Diseases: Still a Role for Total Synthesis

Prof. Adrian DOBBS
UNIVERSITY OF GREENWICH, Kent, United Kingdom

12:15

Lunch

Session 10

Session Chair

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

13:30

PL06 - Multiple Conjugation Reactions on Peptides and Oligonucleotides

Prof. Anna GRANDAS
UNIVERSITY OF BARCELONA, Barcelona, Spain

14:15

IL09 - Heterocycles as a Route to New Chemical Space for Drug Discovery

Prof. James BULL
IMPERIAL COLLEGE, London, United Kingdom

14:45

OC18 - 'Stretched' Analogs of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery

Dr Ivan KONDRATOV
ENAMINE, Kiev, Ukraine

15:00

Coffee break

Session 11

Session Chair

Dr Thomas HEUGEBAERT
UGENT, Gent, Belgium

15:30

OC19 - Regioselective C-H Arylation of Nitro Heterocycles and Further Transformation of Manipulable Nitro Group

Dr Iaroshenko VIKTOR
POLISH ACADEMY OF SCIENCES, Lodz, Poland

15:45

OC20 - Bio-Based Amines from Lignin Derived Monomers

Mr Jeroen BOMON
UNIVERSITEIT ANTWERPEN, Antwerpen, Belgium

16:00

OC21 - Kolbe Anodic Decarboxylation as a Green Way to Access Pyrrolidinones

Ms Mathilde QUERTENMONT
UNIVERSITÉ CATHOLIQUE DE LOUVAIN, La Hulpe, Belgium

16:15

OC22 - Playing with Properties of Biologically Active Compounds: High-Throughput Conjugation of Drug-Like Molecules for Chemical Biology

Ms Sona KRAJCOVICOVA
PALACKY UNIVERSITY, Olomouc, Czech Republic

16:30

Poster Session

19:00

Symposium Banquet

Session 12

Session Chair

Prof. Sven MANGELINCKX
GHENT UNIVERSITY, Ghent, Belgium

10:00

PL07 - Heterocyclic Chemistry in Drug Development

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

10:45

IL10 - Biologically Active Azaheterocycles Containing a Ferrocene Moiety

Prof. Niko S. RADULOVIC
UNIVERSITY OF NIS, Nis, Serbia

11:15

OC23 - Biologically Active Oxygen and Nitrogen Heterocyclic Compounds from Cycloaddition and Conjugate Addition Reactions On Chromones

Prof. Artur M.S. SILVA
UNIVERSITY OF AVEIRO, Aveiro, Portugal

11:30

OC24 - Towards DNA-Encoded Heterocycle Libraries - DNA-Compatible Povarov and Groebke Reactions by Micellar Broensted Acid Catalysis

Dr Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany

11:45

Closing and Award ceremony

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

12:00

Take away Lunch boxes