Bioheterocycles 2019

XVIII International Conference on Heterocycles in Bioorganic Chemistry

 Ghent, Belgium    June 17-20, 2019

Programme

Click on the day below to see the detailed programme.

08:00

Registration

09:10

Opening

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

Session 1

Session Chair

Prof. Christian STEVENS
GHENT UNIVERSITY, Ghent, Belgium

09:30

Heterocycles as Key Features of New Starting Points for Drug Discovery (PL01)

Dr Peter MEIER
NOVARTIS PHARMA AG, Basel, Switzerland

10:15

Development of Enzyme Inhibitors and Multi-target-directed Ligands for Treating Neurodegenerative Diseases (IL01)

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

10:45

Coffee break

Session 2

Session Chair

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:15

Silil-Prins Cyclization: Towards the Synthesis of Medium Sized Heterocycles (OC01)

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:30

Chiral Piperidines from Pyridines: the Meta-Substitution Challenge in Asymmetric Hydrogenation (OC02)

Dr Paul ALSTERS
INNOSYN B.V., Geleen, The Netherlands

11:45

Expanding the Chemical Space of Chiral Trifunctional Building Blocks by Stereoselective Synthesis from Natural Terpenes (IL02)

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

12:15

Lunch

Session 3

Session Chair

Prof. Fawaz ALDABBAGH
KINGSTON UNIVERSITY, London, United Kingdom

13:30

A Journey in Heteroaromatic Scaffolds as Protein Kinase Inhibitors (PL02)

Prof. Pascale MOREAU
UNIVERSITY OF CLERMONT AUVERGNE, Aubičre, France

14:15

Bacterial Quinolones and Derivatives: New Drugs for Bad Bugs (IL03)

Dr Thomas BOTTCHER
UNIVERSITY OF KONSTANZ, Konstanz, Germany

14:45

Hydrogen Peroxide and Hydrohalic Acid-Mediated Synthesis of Ring-Fused Benzimidazolequinone Anti-Cancer Agents (OC03)

Mr Darren CONBOY
KINGSTON UNIVERSITY LONDON, Kingston upon Thames, United Kingdom

15:00

Coffee break

Session 4

Session Chair

Dr Bart ROMAN
GHENT UNIVERSITY, Ghent, Belgium

15:30

Thionations Using a P4S10-Pyridine Complex (OC04)

Ms Ngarita KINGI
VIRONOVA MEDICAL AB, Stockholm, Sweden

15:45

First Solid-Phase Strategy for the Total Synthesis of Fengycin Derivatives, a Class of Cyclic Lipodepsipeptides (OC05)

Dr Lidia FELIU
LIPPSO, UNIVERSITY OF GIRONA, Girona, Spain

16:00

Design and Synthesis of New Nitrogen-Containing Heterocycles for the Treatment of Mechanical Allodynia (OC06)

Ms Alexia VISSEQ
INSTITUT DE CHIMIE DE CLERMONT FERRAND, AUBIERE, France

16:15

ZN(OTF)2-Catalyzed Synthesis of 2-Alkynylazetidines and their Ring Expansion to Functionalized 1,4,5,6-Tetrahydropyridines (OC07)

Dr Aaliya SHEHZADI
INTERNATIONAL ISLAMIC UNIVERSITY, Islamabad, Pakistan

16:30

Poster Session

18:00

Welcome Reception (Ghent City Hall)

Session 5

Session Chair

Prof. Bert MAES
UNIVERSITY OF ANTWERP, Antwerp, Belgium

09:00

Heterocycles To Control Immune Cell Function (PL03)

Prof. David FAIRLIE
UNIVERSITY OF QUEENSLAND, Brisbane, Australia

09:45

Vitamin B12 – an Intriguing Bioheterocycle (IL04)

Prof. Dorota GRYKO
INSTITUTE OF ORGANIC CHEMISTRY PAS, Warsaw, Poland

10:15

Hydroxylated Heterocycles as a Bioisosteric Tool to Modulate the Carboxylic Function (OC08)

Dr Agnese Chiara PIPPIONE
UNIVERSITY OF TURIN, Torino, Italy

10:30

Nanomachine Biocatalysts: Enzymatic Fusions with Tethered Cofactors for Sustainable Industrial Chemistry (OC09)

Dr Andrea NORTH
CSIRO, Parkville, Australia

10:45

Coffee break

Session 6

Session Chair

Prof. Asuncion BARBERO
UNIVERSITY OF VALLADOLID, Valladolid, Spain

11:15

The Magic of Wood and Light – New Concepts for Synthetic Chemistry (OC10)

Prof. Till OPATZ
JOHANNES GUTENBERG-UNIVERSITY, Mainz, Germany

11:30

Synthesis of Enantioenriched 3-Isobenzofuranones Using Chiral Organomagnesiates (OC11)

Dr Sabrina TOUCHET
UNIVERSITÉ DE LORRAINE, Vandoeuvre-les-Nancy, France

11:45

Functionalization of Aromatic Heterocycles Using Bases Derived from LiTMP (IL05)

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

12:15

Lunch

Session 7

Session Chair

Prof. Stanislav GOBEC
UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

13:30

Synthesis of Heterocyles Using Visible Light Photocatalysis (PL04)

Prof. Burkhard KÖNIG
UNIVERSITY OF REGENSBURG, Regensburg, Germany

14:15

Leveraging Carbonylation and N-acyl imine Chemistry in Heterocycle Synthesis (IL06)

Dr Luke ODELL
UNIVERSITY OF UPPSALA, Uppsala, Sweden

14:45

Structurally Simple Cytosine Peptidomimetics as Potent Cardioprotectors in Myocardial Ischemia (MI) Mouse Model: Design, Synthesis And Biological Evaluation (OC12)

Dr Edward KORSHIN
BAR-ILAN UNIVERSITY, Ramat Gan, Israel

15:00

Biradical Formation by Deprotonation in Conjugated 2-Amino/Imino Thiazole Derivatives (OC13)

Prof. Francisco LOPEZ-CALAHORRA
UNIVERSITAT DE BARCELONA, Barcelona, Spain

16:00

Excursion

Session 8

Session Chair

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

09:00

The Beautiful Simplicity of Rearrangements (PL05)

Prof. Nuno MAULIDE
UNIVERSITY OF VIENNA, Vienna, Austria

09:45

A journey with Saponins (IL07)

Dr Martina LAHMANN
BANGOR UNIVERSITY, Wales, United Kingdom

10:15

Small but Selective: Developing Chemical Probes for PKN/PRK2 (OC14)

Ms Fiona SCOTT
SUSSEX DRUG DISCOVERY CENTRE, Falmer, United Kingdom

10:30

Application of Tsunoda reagent to the convenient synthesis of drug-like pyrazoles (OC15)

Dr Olivier LORTHIOIR
ASTRAZENECA, Cambridge, United Kingdom

10:45

Coffee break

Session 9

Session Chair

Prof. Florence MONGIN
UNIVERSITY OF RENNES, Rennes, France

11:15

The Phenanthridine PJ-34 Exclusively Eradicates Human cancer Cells (OC16)

Prof. Malka COHEN-ARMON
TEL-AVIV UNIVERSITY, Tel-Aviv, Israel

11:30

Synthesis and in vitro -Glucosidase Inhibitory Activity of Polyhydroxylated 2-Styrylchromones (OC17)

Dr Clementina SANTOS
INSTITUTO POLITÉCNICO DE BRAGANÇA, Braganca, Portugal

11:45

Heterocycles and Neglected Diseases: Still a Role for Total Synthesis (IL08)

Prof. Adrian DOBBS
UNIVERSITY OF GREENWICH, Kent, United Kingdom

12:15

Lunch

Session 10

Session Chair

Prof. Zsolt SZAKONYI
UNIVERSITY OF SZEGED, Szeged, Hungary

13:30

Multiple Conjugation Reactions on Peptides and Oligonucleotides (PL06)

Prof. Anna GRANDAS
UNIVERSITY OF BARCELONA, Barcelona, Spain

14:15

Heterocycles as a Route to New Chemical Space for Drug Discovery (IL09)

Prof. James BULL
IMPERIAL COLLEGE, London, United Kingdom

14:45

'Stretched' Analogs of Piperidine, Piperazine, and Morpholine: Advanced Building Blocks for Drug Discovery (OC18)

Dr Ivan KONDRATOV
ENAMINE, Kiev, Ukraine

15:00

Coffee break

15:30

Biologically Active Oxygen and Nitrogen Heterocyclic Compounds from Cycloaddition and Conjugate Addition Reactions On Chromones (OC19)

Prof. Artur M.S. SILVA
UNIVERSITY OF AVEIRO, Aveiro, Portugal

Session 11

Session Chair

Dr Thomas HEUGEBAERT
UGENT, Gent, Belgium

15:45

Combining Isocyanides with Carbon Dioxide for Heterocycle Synthesis (OC20)

Mr Jeroen BOMON
UNIVERSITEIT ANTWERPEN, Antwerpen, Belgium

16:00

Kolbe Anodic Decarboxylation as a Green Way to Access Pyrrolidinones (OC21)

Ms Mathilde QUERTENMONT
UNIVERSITÉ CATHOLIQUE DE LOUVAIN, La Hulpe, Belgium

16:15

Playing with Properties of Biologically Active Compounds: High-Throughput Conjugation of Drug-Like Molecules for Chemical Biology (OC22)

Ms Sona KRAJCOVICOVA
PALACKY UNIVERSITY, Olomouc, Czech Republic

16:30

Poster Session

19:00

Symposium Banquet

Session 12

Session Chair

Prof. Sven MANGELINCKX
GHENT UNIVERSITY, Ghent, Belgium

10:00

Heterocyclic Chemistry in Drug Development (PL07)

Prof. Wim DE BORGGRAEVE
KULEUVEN, Heverlee, Belgium

10:45

Biologically Active Azaheterocycles Containing a Ferrocene Moiety (IL10)

Prof. Niko S. RADULOVIC
UNIVERSITY OF NIS, Nis, Serbia

11:15

Regioselective C-H Arylation of Nitro Heterocycles and Further Transformation of Manipulable Nitro Group (OC23)

Dr Iaroshenko VIKTOR
POLISH ACADEMY OF SCIENCES, Lodz, Poland

11:30

Towards DNA-Encoded Heterocycle Libraries - DNA-Compatible Povarov and Groebke Reactions by Micellar Broensted Acid Catalysis (OC24)

Dr Andreas BRUNSCHWEIGER
TU DORTMUND, Dortmund, Germany

11:45

Closing and Award ceremony

Prof. Matthias D'HOOGHE
GHENT UNIVERSITY, Ghent, Belgium

12:00

Take away Lunch boxes